Microstructural changes in the substantia nigra of asymptomatic agricultural workers
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چکیده
منابع مشابه
Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques. Here, we show early signs of aging in SNpc, which are more evident than in ventral tegmental area (VTA), a region adjacent to SNpc but less affected ...
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REFERENCES 1. BALY, F. A., History ofSouthport, Southport, Angus Downie, 1955, p. 37. 2. BmuxmHourr, J., An Essay on the Bite of a Mad Dog, London, R. Baldwin, 1783. 3. British Museum, Add. MS. 36876. 4. FoHRGLL, J., 'The Case of a Hydrophobia', in: Medical Observations and Enquiries, 2nd ed., 1779, vol. 5, p. 195. 5. HBYSHAM, J., Dissertatio Medica de Rabie Canina, Edinburgh, 1777. Information...
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Objective(s): Exercise ameliorates the quality of life and reduces the risk of neurological derangements such as Alzheimer’s (AD) and Parkinson’s disease (PD). Irisin is a product of the physical activity and is a circulating hormone that regulates the energy metabolism in the body. In the nervous system, Irisin influences neurogenesis and neural differentiation in mic...
متن کاملCulture of Substantia Nigra Neurons
Primary cultures of nigral tissue are widely used as a model system to assay effects of trophic and toxic agents on dopaminergic neurons. Cultured dopaminergic neurons have been successfully transplanted in animals and led to behavioral improvement in animal models of Parkinson’s disease. The success of these preclinical studies has encouraged investigators to begin clinical trials using transp...
متن کاملIdentification of proteins in human substantia nigra.
Characterization of the human brain proteome is a critical area of research. While examination of the human cortex has provided some insight, very little is known about the proteome of the human midbrain, which demonstrates substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD). Therefore, characterization of this region is essential to...
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ژورنال
عنوان ژورنال: Neurotoxicology and Teratology
سال: 2014
ISSN: 0892-0362
DOI: 10.1016/j.ntt.2013.12.001